FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway

Fibroblast growth factor-23 (FGF23) is a bone-derived endocrine regulator of phosphate homeostasis which inhibits renal tubular phosphate reabsorption. Binding of circulating FGF23 to FGF receptors in the cell membrane requires the concurrent presence of the co-receptor αKlotho. It is still controve...

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Dades bibliogràfiques
Autors principals: Andrukhova, Olena, Zeitz, Ute, Goetz, Regina, Mohammadi, Moosa, Lanske, Beate, Erben, Reinhold G.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2012
Matèries:
Rapid Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419258/
https://ncbi.nlm.nih.gov/pubmed/22647968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.05.015
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