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Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington’s disease

Huntington’s disease (HD) is a devastating autosomal-dominant neurodegenerative disorder initiated by an abnormally expanded polyglutamine in the huntingtin protein. Determining the contribution of specific factors to the pathogenesis of HD should provide rational targets for therapeutic interventio...

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Bibliografski detalji
Glavni autori: Kumar, Ashish, Kneynsberg, Andrew, Tucholski, Janusz, Perry, Giselle, van Groen, Thomas, Detloff, Peter J., Lesort, Mathieu
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418489/
https://ncbi.nlm.nih.gov/pubmed/22698685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.05.015
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