Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease

Huntington's disease (HD) is an incurable autosomal-dominant neurodegenerative disorder initiated by an abnormally expanded polyglutamine domain in the huntingtin protein. It is proposed that abnormal mitochondrial Ca(2+) capacity results in an increased susceptibility to mitochondrial permeabi...

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Hauptverfasser: Perry, Giselle M., Tallaksen-Greene, Sara, Kumar, Ashish, Heng, Mary Y., Kneynsberg, Andrew, van Groen, Thomas, Detloff, Peter J., Albin, Roger L., Lesort, Mathieu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916705/
https://ncbi.nlm.nih.gov/pubmed/20558522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq247
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