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Changes in mitochondrial DNA alter expression of nuclear encoded genes associated with tumorigenesis
We previously reported the presence of a mtDNA mutation hotspot in UV-induced premalignant and malignant skin tumors in hairless mice. We have modeled this change (9821insA) in murine cybrid cells and demonstrated that this alteration in mtDNA associated with mtBALB haplotype can alter the biochemic...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418480/ https://ncbi.nlm.nih.gov/pubmed/22705584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2012.06.006 |
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