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Identification of a mtDNA mutation hotspot in UV-induced mouse skin tumors producing altered cellular biochemistry
There is increasing awareness of a role of mtDNA alterations in the development of cancer since mtDNA point mutations are found at high frequency in a variety of human tumors. To determine the biological effects of mtDNA mutations in UV-induced skin tumors, hairless mice were irradiated to produce t...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258376/ https://ncbi.nlm.nih.gov/pubmed/22011905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2011.320 |
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