Structure-Guided Directed Evolution of Highly Selective P450-based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin

New tools that allow dynamic visualization of molecular neural events are important for studying the basis of brain activity and disease. Sensors that permit ligand-sensitive magnetic resonance imaging (MRI) are useful reagents due to the non-invasive nature and good temporal and spatial resolution...

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Главные авторы: Brustad, Eric M., Lelyveld, Victor S., Snow, Christopher D., Crook, Nathan, Jung, Sang Taek, Martinez, Francisco M., Scholl, Timothy J., Jasanoff, Alan, Arnold, Frances H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418479/
https://ncbi.nlm.nih.gov/pubmed/22659321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.05.029
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