Structure-Guided Directed Evolution of Highly Selective P450-based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin

New tools that allow dynamic visualization of molecular neural events are important for studying the basis of brain activity and disease. Sensors that permit ligand-sensitive magnetic resonance imaging (MRI) are useful reagents due to the non-invasive nature and good temporal and spatial resolution...

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Détails bibliographiques
Auteurs principaux: Brustad, Eric M., Lelyveld, Victor S., Snow, Christopher D., Crook, Nathan, Jung, Sang Taek, Martinez, Francisco M., Scholl, Timothy J., Jasanoff, Alan, Arnold, Frances H.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418479/
https://ncbi.nlm.nih.gov/pubmed/22659321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.05.029
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