Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

The development of molecular probes that allow in vivo imaging of neural signaling processes with high temporal and spatial resolution remains challenging. Here we applied directed evolution techniques to create magnetic resonance imaging (MRI) contrast agents sensitive to the neurotransmitter dopam...

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Main Authors: Shapiro, Mikhail G, Westmeyer, Gil G, Romero, Philip A, Szablowski, Jerzy O, Küster, Benedict, Shah, Ameer, Otey, Christopher R, Langer, Robert, Arnold, Frances H, Jasanoff, Alan
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073400/
https://ncbi.nlm.nih.gov/pubmed/20190737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1609
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