Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

The development of molecular probes that allow in vivo imaging of neural signaling processes with high temporal and spatial resolution remains challenging. Here we applied directed evolution techniques to create magnetic resonance imaging (MRI) contrast agents sensitive to the neurotransmitter dopam...

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Main Authors: Shapiro, Mikhail G, Westmeyer, Gil G, Romero, Philip A, Szablowski, Jerzy O, Küster, Benedict, Shah, Ameer, Otey, Christopher R, Langer, Robert, Arnold, Frances H, Jasanoff, Alan
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073400/
https://ncbi.nlm.nih.gov/pubmed/20190737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1609
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