Early Sorafenib-Induced Toxicity Is Associated with Drug Exposure and UGTIA9 Genetic Polymorphism in Patients with Solid Tumors: A Preliminary Study

BACKGROUND: Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharma...

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Bibliografische gegevens
Hoofdauteurs: Boudou-Rouquette, Pascaline, Narjoz, Céline, Golmard, Jean Louis, Thomas-Schoemann, Audrey, Mir, Olivier, Taieb, Fabrice, Durand, Jean-Philippe, Coriat, Romain, Dauphin, Alain, Vidal, Michel, Tod, Michel, Loriot, Marie-Anne, Goldwasser, François, Blanchet, Benoit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418266/
https://ncbi.nlm.nih.gov/pubmed/22912756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042875
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