Early Sorafenib-Induced Toxicity Is Associated with Drug Exposure and UGTIA9 Genetic Polymorphism in Patients with Solid Tumors: A Preliminary Study

BACKGROUND: Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharma...

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Hlavní autoři: Boudou-Rouquette, Pascaline, Narjoz, Céline, Golmard, Jean Louis, Thomas-Schoemann, Audrey, Mir, Olivier, Taieb, Fabrice, Durand, Jean-Philippe, Coriat, Romain, Dauphin, Alain, Vidal, Michel, Tod, Michel, Loriot, Marie-Anne, Goldwasser, François, Blanchet, Benoit
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418266/
https://ncbi.nlm.nih.gov/pubmed/22912756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042875
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