Sarcopenia Predicts Early Dose-Limiting Toxicities and Pharmacokinetics of Sorafenib in Patients with Hepatocellular Carcinoma

BACKGROUND: Sorafenib induces frequent dose limiting toxicities (DLT) in patients with advanced hepatocellular carcinoma (HCC). Sarcopenia has been associated with poor performance status and shortened survival in cancer patients. PATIENTS AND METHODS: The characteristics of Child Pugh A cirrhotic p...

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Main Authors: Mir, Olivier, Coriat, Romain, Blanchet, Benoit, Durand, Jean-Philippe, Boudou-Rouquette, Pascaline, Michels, Judith, Ropert, Stanislas, Vidal, Michel, Pol, Stanislas, Chaussade, Stanislas, Goldwasser, François
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364283/
https://ncbi.nlm.nih.gov/pubmed/22666367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037563
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