Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: Implications for development of a therapy for poxvirus infection

The E3L gene product found in all poxviruses is required for the lethality of mice in vaccinia virus infection. Both the C-terminal region, consisting of a double-stranded RNA-binding motif, and the N-terminal region (vZ(E3L)), which is similar to the Zα family of Z-DNA-binding proteins, are require...

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Bibliographic Details
Main Authors: Kim, Yang-Gyun, Lowenhaupt, Ky, Oh, Doo-Byoung, Kim, Kyeong Kyu, Rich, Alexander
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC341766/
https://ncbi.nlm.nih.gov/pubmed/14757814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308260100
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