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Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae

The motor protein cytoplasmic dynein is responsible for most of the minus-end-directed microtubule traffic within cells. Dynein contains four evolutionarily conserved AAA (ATPase associated with various cellular activities) domains that are thought to bind nucleotide; the role of nucleotide binding...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Reck-Peterson, Samara L., Vale, Ronald D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC341754/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14755060/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2637011100
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