Triptolide increases transcript and protein levels of survival motor neurons in human SMA fibroblasts and improves survival in SMA-like mice

BACKGROUND AND PURPOSE: Spinal muscular atrophy (SMA) is a progressive neuromuscular disease. Since disease severity is related to the amount of survival motor neuron (SMN) protein, up-regulated functional SMN protein levels from the SMN2 gene are considered a major SMA drug-discovery strategy. In t...

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Main Authors: Hsu, Ya-Yun, Jong, Yuh-Jyh, Tsai, Hsin-Hung, Tseng, Yu-Ting, An, Li-Mei, Lo, Yi-Ching
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417433/
https://ncbi.nlm.nih.gov/pubmed/22220673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01829.x
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