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Selective Neuromuscular Denervation in Taiwanese Severe SMA Mouse Can Be Reversed by Morpholino Antisense Oligonucleotides

Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease caused by deficiency of the survival of motor neuron (SMN) protein, which leads to synaptic defects and spinal motor neuron death. Neuromuscular junction (NMJ) abnormalities have been found to be involved in SMA pathogenesi...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Lin, Te-Lin, Chen, Tai-Heng, Hsu, Ya-Yun, Cheng, Yu-Hua, Juang, Bi-Tzen, Jong, Yuh-Jyh
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849667/
https://ncbi.nlm.nih.gov/pubmed/27124114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154723
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