Developing peptide-based multivalent antagonists of proliferating cell nuclear antigen and a fluorescence-based PCNA binding assay

Proliferating cell nuclear antigen (PCNA) is a critical player in cell proliferation. It interacts with a myriad of cellular proteins in genomic DNA replication and cell cycle control. This makes PCNA an attractive target for developing antiproliferative therapeutics. Indeed the binding of a human t...

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Bibliographic Details
Main Authors: Bozza, William P., Yang, Kun, Wang, Jialiang, Zhuang, Zhihao
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417354/
https://ncbi.nlm.nih.gov/pubmed/22522186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2012.04.018
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