Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors

There is a critical need for efficacious therapeutic strategies to improve the outcome of patients afflicted by malignant peripheral nerve sheath tumors (MPNST). Multiple lines of evidence suggest a role for deregulated PI3K/mTOR signaling in MPNST, making this axis an attractive target for therapeu...

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Bibliographic Details
Main Authors: Ghadimi, Markus P, Lopez, Gonzalo, Torres, Keila E., Belousov, Roman, Young, Eric D., Liu, Jeffery, Brewer, Kari J., Hoffman, Aviad, Lusby, Kristelle, Lazar, Alexander J, Pollock, Raphael E., Lev, Dina
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416967/
https://ncbi.nlm.nih.gov/pubmed/22848094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0015
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