Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A (DZNeP) with gemcitabine in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is characterized by overexpression of Enhancer-of Zeste-Homolog-2 (EZH2), which plays a pivotal role in cancer-stem-cell (CSC) self-renewal through methylation of histone-H3-lysine-27 (H3K27m3). Against this background, EZH2 was identified as an attractive tar...

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Detalhes bibliográficos
Main Authors: Avan, Amir, Crea, Francesco, Paolicchi, Elisa, Funel, Niccola, Galvani, Elena, Marquez, Victor E, Honeywell, Richard J., Danesi, Romano, Peters, Godefridus J., Giovannetti, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416916/
https://ncbi.nlm.nih.gov/pubmed/22622284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0037
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