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Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
BACKGROUND: The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath. The resulting electrical instability of Aβ-fibers is believed to activate the nociceptive circuitry in Aβ-fibers and initiate...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3416717/ https://ncbi.nlm.nih.gov/pubmed/22676642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-119 |
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