Immunodominant fragments of myelin basic protein initiate T cell-dependent pain

BACKGROUND: The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath. The resulting electrical instability of Aβ-fibers is believed to activate the nociceptive circuitry in Aβ-fibers and initiate...

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Detalhes bibliográficos
Main Authors: Liu, Huaqing, Shiryaev, Sergey A, Chernov, Andrei V, Kim, Youngsoon, Shubayev, Igor, Remacle, Albert G, Baranovskaya, Svetlana, Golubkov, Vladislav S, Strongin, Alex Y, Shubayev, Veronica I
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416717/
https://ncbi.nlm.nih.gov/pubmed/22676642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-119
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