The Human T-Lymphotropic Virus Type 1 Tax Protein Inhibits Nonsense-Mediated mRNA Decay by Interacting with INT6/EIF3E and UPF1

In this report, we analyzed whether the degradation of mRNAs by the nonsense-mediated mRNA decay (NMD) pathway was affected in human T-lymphotropic virus type 1 (HTLV-1)-infected cells. This pathway was indeed strongly inhibited in C91PL, HUT102, and MT2 cells, and such an effect was also observed b...

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Main Authors: Mocquet, Vincent, Neusiedler, Julia, Rende, Francesca, Cluet, David, Robin, Jean-Philippe, Terme, Jean-Michel, Duc Dodon, Madeleine, Wittmann, Jürgen, Morris, Christelle, Le Hir, Hervé, Ciminale, Vincenzo, Jalinot, Pierre
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416306/
https://ncbi.nlm.nih.gov/pubmed/22553336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07021-11
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