The “Bridge” in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection

Replication of the human herpesvirus Epstein-Barr virus drastically impairs cellular protein synthesis. This shutoff phenotype results from mRNA degradation upon expression of the early lytic-phase protein BGLF5. Interestingly, BGLF5 is the viral DNase, or alkaline exonuclease, homologues of which a...

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Detalhes bibliográficos
Main Authors: Horst, Daniëlle, Burmeister, Wim P., Boer, Ingrid G. J., van Leeuwen, Daphne, Buisson, Marlyse, Gorbalenya, Alexander E., Wiertz, Emmanuel J. H. J., Ressing, Maaike E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416140/
https://ncbi.nlm.nih.gov/pubmed/22696660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00309-12
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