Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations

Background. Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise from mutations in gyrA (intermediate resistance) or gyrA and parC (resistance). Here we tested the consequence of commonly isolated gyrA(91/95) and parC(86) mutations on gonococcal fitness. Methods. Mutant gyrA(91/95) and parC(86) al...

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Detalhes bibliográficos
Main Authors: Kunz, Anjali N., Begum, Afrin A., Wu, Hong, D'Ambrozio, Jonathan A., Robinson, James M., Shafer, William M., Bash, Margaret C., Jerse, Ann E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415892/
https://ncbi.nlm.nih.gov/pubmed/22492860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis277
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