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Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1

We have previously demonstrated proteasomal degradation of DNMT1 in mammalian cells following treatment with several DNA hypomethylating agents. Here, we demonstrate dose-dependent degradation of Dnmt1 in mouse embryonic stem (ES) cells expressing catalytic site mutant (cys-ser), confirming that the...

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Autors principals: Datta, Jharna, Ghoshal, Kalpana, Motiwala, Tasneem, Jacob, Samson T.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415671/
https://ncbi.nlm.nih.gov/pubmed/22893792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912452665
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