Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes

Neuroinvasion and subsequent destruction of the central nervous system by prions are typically preceded by a colonization phase in lymphoid organs. An important compartment harboring prions in lymphoid tissue is the follicular dendritic cell (FDC), which requires both tumor necrosis factor receptor...

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Bibliographic Details
Main Authors: O'Connor, Tracy, Frei, Nathalie, Sponarova, Jana, Schwarz, Petra, Heikenwalder, Mathias, Aguzzi, Adriano
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415451/
https://ncbi.nlm.nih.gov/pubmed/22912582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002867
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