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Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1
Oncogenes, which are essential for tumor initiation, development, and maintenance, are valuable targets for cancer therapy. However, it remains a challenge to effectively inhibit oncogene activity by targeting their downstream pathways without causing significant toxicity to normal tissues. Here we...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3415433/ https://ncbi.nlm.nih.gov/pubmed/22916024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002855 |
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