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Nanoemulsion liquid preconcentrates for raloxifene hydrochloride: optimization and in vivo appraisal

Raloxifene hydrochloride (RLX) is a selective estrogen-receptor modulator for treatment of osteoporosis and prevention of breast and endometrial cancer. By virtue of extensive presystemic clearance, RLX bioavailability is only 2%. The current study aimed to tailor and characterize RLX-loaded self-na...

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Autores principales: Elsheikh, Manal A, Elnaggar, Yosra SR, Gohar, Eman Y, Abdallah, Ossama Y
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414224/
https://ncbi.nlm.nih.gov/pubmed/22888234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S33186
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