Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

BACKGROUND AND PURPOSE: mTOR inhibitors are currently used as immunosuppressants in transplanted patients and as promising anti-cancer agents. However, new-onset diabetes is a frequent complication occurring in patients treated with mTOR inhibitors such as rapamycin (Sirolimus). Here, we investigate...

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Detalhes bibliográficos
Main Authors: Deblon, N, Bourgoin, L, Veyrat-Durebex, C, Peyrou, M, Vinciguerra, M, Caillon, A, Maeder, C, Fournier, M, Montet, X, Rohner-Jeanrenaud, F, Foti, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413866/
https://ncbi.nlm.nih.gov/pubmed/22014210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01716.x
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