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Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn

Libraries based on an isolated human immunoglobulin G1 (IgG1) constant domain 2 (CH2) have been previously diversified by random mutagenesis. However, native isolated CH2 is not very stable and the generation of many mutations could lead to an increase in immunogenicity. Recently, we demonstrated th...

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Autori principali: Gong, Rui, Wang, Yanping, Ying, Tianlei, Dimitrov, Dimiter S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413693/
https://ncbi.nlm.nih.gov/pubmed/22879932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042288
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