Loss of ATM kinase activity leads to embryonic lethality in mice

Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) damage signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis. The majority of patients with A-T, a cancer-prone neurodegenerative disease, present with null mutations in Atm. To determine wheth...

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Bibliographic Details
Main Authors: Daniel, Jeremy A., Pellegrini, Manuela, Lee, Baeck-Seung, Guo, Zhi, Filsuf, Darius, Belkina, Natalya V., You, Zhongsheng, Paull, Tanya T., Sleckman, Barry P., Feigenbaum, Lionel, Nussenzweig, André
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2012
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413361/
https://ncbi.nlm.nih.gov/pubmed/22869595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201204035
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