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Synthetic studies toward (+)-cortistatin A

We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6π-electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the...

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Autors principals: Wang, Zhang, Dai, Mingji, Park, Peter K., Danishefsky, Samuel J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413295/
https://ncbi.nlm.nih.gov/pubmed/22879684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.10.026
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