Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like features in white adipose (WAT) is an attractive, if elusive therapeutic approach to staunch the current obesity epidemic. Here we report that gain-of-function of the NAD-dependent deacetylase SirT1 or loss-of-function...

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Main Authors: Qiang, Li, Wang, Liheng, Kon, Ning, Zhao, Wenhui, Lee, Sangkyu, Zhang, Yiying, Rosenbaum, Michael, Zhao, Yingming, Gu, Wei, Farmer, Stephen R., Accili, Domenico
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413172/
https://ncbi.nlm.nih.gov/pubmed/22863012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.027
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