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Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence
Telomeres are transcribed into non-coding TElomeric Repeat containing RNAs (TERRA). We have employed a transcriptionally inducible telomere to investigate how telomere transcription affects telomere function in Saccharomyces cerevisiae. We report that telomere shortening resulting from high levels o...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413150/ https://ncbi.nlm.nih.gov/pubmed/22553368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks358 |
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