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Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence
Telomeres are transcribed into non-coding TElomeric Repeat containing RNAs (TERRA). We have employed a transcriptionally inducible telomere to investigate how telomere transcription affects telomere function in Saccharomyces cerevisiae. We report that telomere shortening resulting from high levels o...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413150/ https://ncbi.nlm.nih.gov/pubmed/22553368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks358 |
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