Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence

Telomeres are transcribed into non-coding TElomeric Repeat containing RNAs (TERRA). We have employed a transcriptionally inducible telomere to investigate how telomere transcription affects telomere function in Saccharomyces cerevisiae. We report that telomere shortening resulting from high levels o...

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Hlavní autoři: Maicher, André, Kastner, Lisa, Dees, Martina, Luke, Brian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413150/
https://ncbi.nlm.nih.gov/pubmed/22553368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks358
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