Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

Metastasis and disease relapse are hypothesized to result from tumor initiating cells (TICs). Previously, we have defined a CD44+/CD24−/low mammosphere-forming tumorigenic 493-gene signature in breast cancer. Stat3 was identified as a critical node in self-renewal based on an ongoing lentiviral shRN...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Dave, Bhuvanesh, Landis, Melissa D., Dobrolecki, Lacey E., Wu, Meng-Fen, Zhang, Xiaomei, Westbrook, Thomas F., Hilsenbeck, Susan G., Liu, Dan, Lewis, Michael T., Tweardy, David J., Chang, Jenny C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412855/
https://ncbi.nlm.nih.gov/pubmed/22879872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030207
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados