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TGF-β Sensitivity Restrains CD8+ T Cell Homeostatic Proliferation by Enforcing Sensitivity to IL-7 and IL-15

The pleiotropic cytokine TGF-β has been implicated in the regulation of numerous aspects of the immune response, including naïve T cell homeostasis. Previous studies found that impairing TGF-β responsiveness (through expression of a dominant-negative TGF-β RII [DNRII] transgene) leads to accumulatio...

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Detalhes bibliográficos
Main Authors: Johnson, Lisa D. S., Jameson, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412850/
https://ncbi.nlm.nih.gov/pubmed/22879925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042268
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