SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

Mice that are deficient in suppressor of cytokine signaling–1 (SOCS-1) succumb to neonatal mortality that is associated with extensive cellular infiltration of many tissues. T cells seem to be necessary for disease, which can be alleviated largely by neutralizing interferon-γ. Examining T cell recep...

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Main Authors: Davey, Gayle M., Starr, Robyn, Cornish, Ann L., Burghardt, J. Theodore, Alexander, Warren S., Carbone, Francis R., Surh, Charles D., Heath, William R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213211/
https://ncbi.nlm.nih.gov/pubmed/16216888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050003
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