IL-7 is critical for homeostatic proliferation and survival of naïve T cells

In T cell-deficient conditions, naïve T cells undergo spontaneous “homeostatic” proliferation in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and IL-15 enhanced...

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Bibliografiske detaljer
Main Authors: Tan, Joyce T., Dudl, Eric, LeRoy, Eric, Murray, Richard, Sprent, Jonathan, Weinberg, Kenneth I., Surh, Charles D.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC37504/
https://ncbi.nlm.nih.gov/pubmed/11447288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161126098
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