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HIV-1 Envelope Resistance to Proteasomal Cleavage: Implications for Vaccine Induced Immune Responses

BACKGROUND: Antigen processing involves many proteolytic enzymes such as proteasomes and cathepsins. The processed antigen is then presented on the cell surface bound to either MHC class I or class II molecules and induces/interacts with antigen-specific CD8+ and CD4+ T-cells, respectively. Prelimin...

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Detalhes bibliográficos
Main Authors: Steers, Nicholas J., Ratto-Kim, Silvia, de Souza, Mark S., Currier, Jeffrey R., Kim, Jerome H., Michael, Nelson L., Alving, Carl R., Rao, Mangala
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412807/
https://ncbi.nlm.nih.gov/pubmed/22880042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042579
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