Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy

BACKGROUND: The importance of ERBB2/NEU/HER2 in the response of breast tumours to the heat shock protein 90 (HSP90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG; tanespimycin) has been demonstrated in the clinic. ERBB2 is an oncoprotein client that is highly dependent on HSP90. This and...

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Main Authors: Rodrigues, Loreta M, Chung, Yuen-Li, Al Saffar, Nada M S, Sharp, Swee Y, Jackson, Laura E, Banerji, Udai, Stubbs, Marion, Leach, Martin O, Griffiths, John R, Workman, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412754/
https://ncbi.nlm.nih.gov/pubmed/22621282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-5-250
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