Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease

Alzheimer’s disease (AD), the most common dementia, is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein, and their deposition as amyloid plaques and neurofibrillary tangles (NFTs). Tau aggregation also occurs in other common neurodegenerative diseases. Frontotemporal...

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Bibliografiske detaljer
Main Authors: Ho, Shuk Wai, Tsui, Yuk Tung Chanel, Wong, Ting Ting, Cheung, Stanley Kwok-Kuen, Goggins, William B, Yi, Lau Ming, Cheng, Kwok Kin, Baum, Larry
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878847/
https://ncbi.nlm.nih.gov/pubmed/24344631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2047-9158-2-24
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