Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease

Alzheimer’s disease (AD), the most common dementia, is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein, and their deposition as amyloid plaques and neurofibrillary tangles (NFTs). Tau aggregation also occurs in other common neurodegenerative diseases. Frontotemporal...

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Detalhes bibliográficos
Main Authors: Ho, Shuk Wai, Tsui, Yuk Tung Chanel, Wong, Ting Ting, Cheung, Stanley Kwok-Kuen, Goggins, William B, Yi, Lau Ming, Cheng, Kwok Kin, Baum, Larry
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878847/
https://ncbi.nlm.nih.gov/pubmed/24344631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2047-9158-2-24
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