A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) in Patients with Hormone-Refractory Metastatic Prostate Cancer

PURPOSE: 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) is a benzoquinone ansamycin antibiotic with anti-proliferative activity in several mouse xenograft models including prostate cancer models. A two-stage phase II study was conducted to assess the activity and toxicity profile of 17-AAG administ...

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Главные авторы: Heath, Elisabeth I., Hillman, David W., Vaishampayan, Ulka, Sheng, Shijie, Sarkar, Fazlul, Harper, Felicity, Gaskins, Melvin, Pitot, Henry C., Tan, Winston, Ivy, S. Percy, Pili, Roberto, Carducci, Michael A., Liu, Glenn
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085545/
https://ncbi.nlm.nih.gov/pubmed/19047126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0221
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