A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) in Patients with Hormone-Refractory Metastatic Prostate Cancer

PURPOSE: 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) is a benzoquinone ansamycin antibiotic with anti-proliferative activity in several mouse xenograft models including prostate cancer models. A two-stage phase II study was conducted to assess the activity and toxicity profile of 17-AAG administ...

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Main Authors: Heath, Elisabeth I., Hillman, David W., Vaishampayan, Ulka, Sheng, Shijie, Sarkar, Fazlul, Harper, Felicity, Gaskins, Melvin, Pitot, Henry C., Tan, Winston, Ivy, S. Percy, Pili, Roberto, Carducci, Michael A., Liu, Glenn
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085545/
https://ncbi.nlm.nih.gov/pubmed/19047126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0221
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