A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) in Patients with Hormone-Refractory Metastatic Prostate Cancer

PURPOSE: 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) is a benzoquinone ansamycin antibiotic with anti-proliferative activity in several mouse xenograft models including prostate cancer models. A two-stage phase II study was conducted to assess the activity and toxicity profile of 17-AAG administ...

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Bibliografiske detaljer
Main Authors: Heath, Elisabeth I., Hillman, David W., Vaishampayan, Ulka, Sheng, Shijie, Sarkar, Fazlul, Harper, Felicity, Gaskins, Melvin, Pitot, Henry C., Tan, Winston, Ivy, S. Percy, Pili, Roberto, Carducci, Michael A., Liu, Glenn
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085545/
https://ncbi.nlm.nih.gov/pubmed/19047126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0221
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