Enhanced hepatocarcinogenesis in mouse models and human HCC by coordinate KLF6 depletion and increased mRNA splicing

BACKGROUND: KLF6-SV1 (SV1), the major splice variant of KLF6, antagonizes the KLF6 tumor suppressor by an unknown mechanism. Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown. We sought to define th...

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Hauptverfasser: Vetter, Diana, Cohen-Naftaly, Michal, Villaneuva, Augusto, Lee, Youngmin A., Kocabayoglu, Peri, Hannivoort, Rebekka, Narla, Goutham, Llovet, Josep Maria, Thung, Swan N., Friedman, Scott L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412196/
https://ncbi.nlm.nih.gov/pubmed/22535637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25810
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