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Unexpected role for MHC II–peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo
Here we report a unique role for MHC II–peptide complexes in controlling immune responses of naïve CD8 T cells. Compared with CD8 T cells from WT mice, CD8 T cells isolated from MHC II(−/−) mice hyperproliferated under lymphopenic conditions, differentiated into effector cells producing proinflammat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411949/ https://ncbi.nlm.nih.gov/pubmed/22802622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207219109 |
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