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Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-Kras(G12D)-LSL-Trp53(R172H)-Pdx1-Cre mice
There are several studies supporting the role of HMG-CoA reductase inhibitors such as atorvastatin against carcinogenesis, in which inhibiting the generation of prenyl intermediates involved in protein prenylation plays the crucial role. Mutation of Kras gene is the most common genetic alteration in...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411900/ https://ncbi.nlm.nih.gov/pubmed/22549877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.21916 |
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