Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-Kras(G12D)-LSL-Trp53(R172H)-Pdx1-Cre mice

There are several studies supporting the role of HMG-CoA reductase inhibitors such as atorvastatin against carcinogenesis, in which inhibiting the generation of prenyl intermediates involved in protein prenylation plays the crucial role. Mutation of Kras gene is the most common genetic alteration in...

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Autores principales: Liao, Jie, Chung, Yeon Tae, Yang, Allison L, Zhang, Meng, Li, Haonan, Zhang, Wanying, Yan, Liang, Yang, Guang-Yu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411900/
https://ncbi.nlm.nih.gov/pubmed/22549877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.21916
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