Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+);LSL-Trp53(R172H/+);Pdx-1-Cre), Its Variants and Their Application in Immuno-oncology Drug Discovery

Pancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer-related deaths in the United States and for patients with unresectable disease, treatment options are currently limited and lack curative potential. Preclinical mouse models of PDAC that recapitulate the biology of human pancreatic ca...

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Detalhes bibliográficos
Publicado no:Curr Protoc Pharmacol
Main Authors: Lee, Jae W., Komar, Chad A., Bengsch, Fee, Graham, Kathleen, Beatty, Gregory L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915217/
https://ncbi.nlm.nih.gov/pubmed/27248578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.2
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