Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+);LSL-Trp53(R172H/+);Pdx-1-Cre), Its Variants and Their Application in Immuno-oncology Drug Discovery

Pancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer-related deaths in the United States and for patients with unresectable disease, treatment options are currently limited and lack curative potential. Preclinical mouse models of PDAC that recapitulate the biology of human pancreatic ca...

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Detalles Bibliográficos
Publicado en:Curr Protoc Pharmacol
Main Authors: Lee, Jae W., Komar, Chad A., Bengsch, Fee, Graham, Kathleen, Beatty, Gregory L.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915217/
https://ncbi.nlm.nih.gov/pubmed/27248578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.2
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