Enhanced ADCC Activity of Affinity Maturated and Fc-Engineered Mini-Antibodies Directed against the AML Stem Cell Antigen CD96

CD96, a cell surface antigen recently described to be preferentially expressed on acute myeloid leukemia (AML) leukemic stem cells (LSC) may represent an interesting target structure for the development of antibody-based therapeutic approaches. The v-regions from the CD96-specific hybridoma TH-111 w...

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Bibliographische Detailangaben
Hauptverfasser: Mohseni Nodehi, Sahar, Repp, Roland, Kellner, Christian, Bräutigam, Joachim, Staudinger, Matthias, Schub, Natalie, Peipp, Matthias, Gramatzki, Martin, Humpe, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411760/
https://ncbi.nlm.nih.gov/pubmed/22879978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042426
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