Crucial Role of TSC-22 in Preventing the Proteasomal Degradation of p53 in Cervical Cancer

The p53 tumor suppressor function can be compromised in many tumors by the cellular antagonist HDM2 and human papillomavirus oncogene E6 that induce p53 degradation. Restoration of p53 activity has strong therapeutic potential. Here, we identified TSC-22 as a novel p53-interacting protein and show i...

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Библиографические подробности
Главные авторы: Yoon, Cheol-Hee, Rho, Seung Bae, Kim, Seong-Tae, Kho, Seongho, Park, Junsoo, Jang, Ik-Soon, Woo, Seonock, Kim, Sung Soon, Lee, Je-Ho, Lee, Seung-Hoon
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411576/
https://ncbi.nlm.nih.gov/pubmed/22870275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042006
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